ABSTRACT
Objective:To investigate the clinical efficacy and adverse reactions of linezolid in the treatment of gram-positive coccal infections after chemotherapy in older adult patients with leukemia.Methods:Ninety-two older adult patients with leukemia complicated by gram-positive coccal infections, who received treatment in Yiwu Central Hospital from January 2017 to December 2019, were included in this study. They were randomly assigned to receive routine anti-infection treatment (control group, n = 46) or linezolid treatment (observation group, n = 46). Clinical efficacy, the time required for body temperature restoring to normal, and medication time were compared between the two groups. Results:Total response rate was significantly higher in the observation group than in the control group [95.65% (44 /46) vs. 78.26% (36/46), χ2 = 6.13, P = 0.013]. The time required for body temperature restoring to normal and medication time in the observation group were (7.98 ± 1.04) days and (8.58 ± 1.31) days, respectively, which were significantly shorter than those in the control group [(8.85 ± 1.47) days, (9.46 ± 2.52) days, t = 3.27, 2.10, P = 0.001, 0.019). The incidence of adverse reactions was significantly lower in the observation group than in the control group [4.35% (2/46) vs. 19.57% (9/46), χ2 = 5.05, P < 0.05]. Conclusion:Linezolid is highly effective on gram-positive coccal infections after chemotherapy in older adult patients with leukemia. Linezolid treatment requires comparatively shorter time required for body temperature restoring to normal and shorter medication time and is safer than routine anti-infection treatment.
ABSTRACT
Objective To investigate the effect after operation infection in the department of orthopedics in our hospital,and to explore the use of antibiotics to prevent infection treatment best administration time,duration of drugs and the effect of several drug combination therapy.Methods 492 patients were randomly divided into A,B,C groups,A group included 163 cases in β-lactam and Aminoglycosides,B group was 162 cases in β-lactam and Macrolide,C group 167 cases were in two β-lactam.Comparison of three groups of anti-infection treatment.Results Preoperative administration of 0.5 ～ 2h efficiency was 97.4％,preoperative 3 ～ 24h efficiency was 94.5％,both difference was statistically significant(x2 =4.97,P ＜0.05) ; medication persistence time ＜ 24h effective rate reached 92.3％,medication duration 24h to 3d efficiency 96.8％,use duration of 4 ～7d effective rate was 83.5％,the use of antibiotics of short duration group had significantly higher efficiency long service group,significant difference (x2 =6.19,P ＜0.05).A,B,C group combined medication against infection of total effectiveness respectively was 95.3％,94.5％,95.2％,which was not statistically significant (F =0.16,P ＞ 0.05).Conclusion Operation before the use of antibiotic prophylaxis against infection effect is good,several antibiotics combined with medication regimens has no significant difference in efficiency.